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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CMIP All Species: 23.33
Human Site: Y718 Identified Species: 57.04
UniProt: Q8IY22 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY22 NP_085132.1 739 82975 Y718 T K L S A D T Y E D L K A K L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001109725 1040 115469 Y1019 T K L S A D T Y E D L K A K L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9D486 739 82826 Y718 T K L S A D T Y E D L K A K L
Rat Rattus norvegicus Q5MJ12 479 51833 T461 L T N C P G A T P E L F K Y F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507966 653 73509 L635 S A D T Y E D L K A K L P N L
Chicken Gallus gallus XP_423491 772 86619 Y751 T K L S A D T Y E D L K A K L
Frog Xenopus laevis A1L3F5 739 83452 Y718 T K L S A D T Y E D L K A K L
Zebra Danio Brachydanio rerio XP_690387 687 76914 Y666 T K L T A D T Y E D L K A K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397222 587 65892 L569 S V Q T F E S L K K C L P A L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001147302 582 63441 N563 D S T R V T A N E M R K L R A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 67.8 N.A. N.A. 98.7 21.1 N.A. 81.7 91.1 92.2 80.2 N.A. N.A. 35.9 N.A. N.A.
Protein Similarity: 100 N.A. 69.4 N.A. N.A. 99.1 33.4 N.A. 84.7 93.2 95.9 84.5 N.A. N.A. 52 N.A. N.A.
P-Site Identity: 100 N.A. 100 N.A. N.A. 100 6.6 N.A. 6.6 100 100 93.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 N.A. 100 N.A. N.A. 100 13.3 N.A. 33.3 100 100 100 N.A. N.A. 40 N.A. N.A.
Percent
Protein Identity: N.A. 22 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 37.7 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 60 0 20 0 0 10 0 0 60 10 10 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 10 0 10 0 0 60 10 0 0 60 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 20 0 0 70 10 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 10 % F
% Gly: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 60 0 0 0 0 0 0 20 10 10 70 10 60 0 % K
% Leu: 10 0 60 0 0 0 0 20 0 0 70 20 10 0 80 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 0 10 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 10 0 0 0 10 0 0 0 20 0 0 % P
% Gln: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 10 0 0 10 0 % R
% Ser: 20 10 0 50 0 0 10 0 0 0 0 0 0 0 0 % S
% Thr: 60 10 10 30 0 10 60 10 0 0 0 0 0 0 0 % T
% Val: 0 10 0 0 10 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 60 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _